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Technology - FAQs - COSMEDERM-7™
What is COSMEDERM-7™?
What does COSMEDERM-7™ do?
Why is COSMEDERM-7™ commercially important?
Is COSMEDERM-7™ patented?
How does COSMEDERM-7™ work?
Is COSMEDERM-7™ safe?
How has COSMEDERM-7™ been clinically tested?
What are some product applications for COSMEDERM-7™?
How does COSMEDERM-7™ improve the efficacy
of products?
Q: What is COSMEDERM-7™?
A: COSMEDERM-7™ is the natural element strontium.
It is a soft yellow-white metal that is chemically similar to
calcium and is widely found in nature and in humans. It is the
8th most abundant element in seawater and is found in the foods
we eat, especially in green leafy vegetables. Discovered by
Gary S. Hahn, M.D. a San Diego, California-based Cosmederm Technologies
to have powerful anti-irritant properties, strontium is known
commercially as COSMEDERM-7™. This patented anti-irritant
compound dramatically suppresses sensory irritation - without
side effects.
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Q: What does COSMEDERM-7™ do?
A: Double-blind, vehicle-controlled, random-treatment assignment
human clinical studies demonstrate that COSMEDERM-7™ can
substantially block the stinging, burning, itching and redness
response that can be caused by a wide variety of chemical irritants,
including alpha and beta-hydroxy acids (AHAs & BHAs), anti-perspirants
& deodorants, anti-acne agents, vitamin C, depilatories,
hair care products and many other ingredients used in cosmetics,
personal care products and pharmaceuticals. COSMEDERM-7™
is effective as a pre-treatment to protect skin from chemical
and environmental irritation, formulated in combination with
an irritating ingredient, or even when used after irritation
has started as in allergic skin reactions.
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Q: Why is COSMEDERM-7™ commercially important?
A: Irritation is a major commercial problem for cosmetics
and personal care products manufacturers. In fact, the efficacy
of many products is frequently limited due to the irritating
effects of their active ingredients. By reducing irritation,
COSMEDERM-7™ enables more effective products to be made
without the side effects of stinging, itching, burning and redness.
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Q: Is COSMEDERM-7™ patented?
A: Cosmederm Technologies has extensive patent protection for
COSMEDERM-7™, including two U.S. patents and patents issued
or pending in 25 countries.
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Q: How does COSMEDERM-7™ work?
A: COSMEDERM-7™’s anti-irritant activity is believed
to be due to its ability to block neurogenic inflammation. The
skin and other organs are innervated by a fine network of unmyelinated
sensory nerves (type "C" neurons) that respond to
chemical, thermal and mechanical stimuli. These polymodal sensory
nerves act as skin-irritant receptors and respond to noxious
stimuli that may cause tissue damage. When activated by chemical
irritants, skin-irritant receptors ("nociceptors")
transmit sensations of itching, burning, stinging and diffuse
burning pain. COSMEDERM-7™ is believed to block one of
the earliest steps in the neurogenic inflammatory cascade, thus
blocking sensory irritation sensations and subsequent tissue-destructive
inflammatory reactions. Since chemically sensitive nociceptors
do not transmit sensations of touch, pressure or localized pain,
COSMEDERM-7™ does not product numbness or a reduced response
to painful stimuli, as would a local anesthetic such as Lidocaine.
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Q: Is COSMEDERM-7™ safe?
A: COSMEDERM-7™ is remarkably safe — in some studies
as safe as calcium, and is made from natural ingredients. More
than 10,000 human test exposures indicate that the compound
has no known side effects. It is the 8th most abundant element
in sea water, is found in green leafy vegetables, and 0.8-5
mg. are consumed daily by humans. One form of COSMEDERM-7™
has been approved in the European Union after an extensive safety
review.
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Q: How has COSMEDERM-7™ been clinically tested?
A: The clinical studies in which COSMEDERM-7™ was tested
were designed and executed according to the highest scientific
standards: Double blind, vehicle-controlled, random treatment
assignment trials, so that neither the clinical technicians
nor the subjects knew which formulas were used.
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Q: What are some product applications for COSMEDERM-7™?
A: Human clinical studies conducted both by Cosmederm scientists
and by independent research laboratories confirm that COSMEDERM-7™
effectively suppresses the sting, burn, itch and redness responses
caused by a broad range of topically applied chemical irritants
now used in cosmetics, personal care products and pharmaceuticals.
Exciting new data, published in peer-reviewed medical journals,
demonstrate that COSMEDERM-7™ can also reduce itch caused
by allergic skin reactions, thus suggesting many new applications
to protect the skin from environmentally-induced irritation.
COSMEDERM-7™ is chemically stable in topical formulations
and is compatible with a wide range of product formulations
and ingredients, including fragrances and preservatives.
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Q: How does COSMEDERM-7™ improve the efficacy of products?
A: COSMEDERM-7™ allows products to be formulated
with the highest concentrations of active ingredients that would
otherwise be too irritating for consumer use. Alpha-hydroxy
acids, for example, produce the most substantial "anti-aging"
effects when they have both a high concentration and low pH
(high acidity) — a combination that can be highly irritating.
COSMEDERM-7™ allows AHA products to have such optimal
conditions, thus producing the highest level of efficacy and
extraordinary comfort.
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